{"id":50742,"date":"2025-09-29T20:53:06","date_gmt":"2025-09-29T20:53:06","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/50742\/"},"modified":"2025-09-29T20:53:06","modified_gmt":"2025-09-29T20:53:06","slug":"mayo-clinic-study-finds-genetic-factor-linked-to-liver-damage-in-cancer-patients-news","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/50742\/","title":{"rendered":"Mayo Clinic study finds genetic factor linked to liver damage in cancer patients | News"},"content":{"rendered":"<p>ROCHESTER, Minn. \u2014 Mayo Clinic researchers have discovered a genetic factor that may explain why some colorectal cancer patients experience severe liver damage after chemotherapy.<\/p>\n<p>This finding could impact treatment strategies for patients with colorectal liver metastases. Patrick Starlinger, M.D., Ph.D., a surgeon at Mayo Clinic, said the <a href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(25)00372-X\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">study<\/a> is the first to show a genetic predisposition influences how the liver tolerates chemotherapy.<\/p>\n<p>The research examined 551 patients who underwent chemotherapy followed by surgery, identifying a specific PNPLA3 gene variant linked to liver injury. Doctors say this variant is prevalent worldwide but varies among populations, being more common in individuals of Asian or Latin American descent.<\/p>\n<p>This genetic insight may clarify why previous studies have shown varied results regarding chemotherapy&#8217;s benefits before and after surgery.<\/p>\n<p>Dr. Starlinger emphasized that a blood test for the PNPLA3 variant, combined with monitoring liver health, could help identify patients at higher risk for liver damage. &#8220;These findings offer us insight into how we can adjust treatment strategies to best manage the care for patients diagnosed with colorectal liver metastases,&#8221; Starlinger said, noting the potential to personalize treatment to minimize chemotherapy&#8217;s risks.<\/p>\n","protected":false},"excerpt":{"rendered":"ROCHESTER, Minn. \u2014 Mayo Clinic researchers have discovered a genetic factor that may explain why some colorectal cancer&hellip;\n","protected":false},"author":2,"featured_media":50743,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[2534,2535,405,43887,10851,111,139,69,43888,147,383],"class_list":["post-50742","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","tag-cancer","tag-chemotherapy","tag-genetics","tag-liver-damage","tag-mayo-clinic","tag-new-zealand","tag-newzealand","tag-nz","tag-patrick-starlinger","tag-science","tag-study"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/50742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=50742"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/50742\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/50743"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=50742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=50742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=50742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}