{"id":565389,"date":"2026-08-11T05:40:10","date_gmt":"2026-08-11T05:40:10","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/565389\/"},"modified":"2026-08-11T05:40:10","modified_gmt":"2026-08-11T05:40:10","slug":"three-models-three-routes-to-altered-auditory-processing-and-more","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/565389\/","title":{"rendered":"Three models, three routes to altered auditory processing, and more"},"content":{"rendered":"<p>Hear, hear: A comparison of brain activity in three genetic models of autism demonstrated different mechanisms that lead to changes in auditory processing, according to a new <a href=\"https:\/\/doi.org\/10.1523\/JNEUROSCI.0364-26.2026\" target=\"_blank\" rel=\"nofollow noopener\">study<\/a> in zebrafish. The genetic lines examined\u2014each carrying variants of FMR1, MECP2 or CNTNAP2\u2014displayed altered sensory behaviors, such as hyper-responsiveness and reduced habituation. As for brain circuitry, the FMR1 model showed increased activity in the auditory regions and an imbalance in excitatory versus inhibitory activity, whereas the other models showed differences in network activity over time. All three models showed altered brain activity in sensory integration and sensorimotor gating regions. The authors conclude that their comparison \u201csuggests that diverse genetic factors may contribute to similar behavioral effects through a range of circuit- and network-scale mechanisms.\u201d<\/p>\n<p>Autism research spotted this week:<\/p>\n<p>\u201cClinical, cellular, and genomic consequences of a population-enriched SETD1A missense variant\u201d <a href=\"https:\/\/doi.org\/10.21203\/rs.3.rs-9900286\/v1\" target=\"_blank\" rel=\"nofollow noopener\">Research Square<\/a><br \/>\n\u201cThe linker histone H1.4 condenses chromatin in maturing postmitotic neurons\u201d <a href=\"https:\/\/doi.org\/10.64898\/2026.07.28.741367\" target=\"_blank\" rel=\"nofollow noopener\">bioRxiv<\/a><br \/>\n\u201cImpaired astrocyte-to-neuron cholesterol trafficking drives synaptic dysfunction in Rett syndrome\u201d <a href=\"https:\/\/doi.org\/10.64898\/2026.07.29.741426\" target=\"_blank\" rel=\"nofollow noopener\">bioRxiv<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Hear, hear: A comparison of brain activity in three genetic models of autism demonstrated different mechanisms that lead&hellip;\n","protected":false},"author":2,"featured_media":565390,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[111,139,69,147],"class_list":["post-565389","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-new-zealand","tag-newzealand","tag-nz","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/565389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=565389"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/565389\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/565390"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=565389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=565389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=565389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}