{"id":569011,"date":"2026-08-14T17:36:16","date_gmt":"2026-08-14T17:36:16","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/569011\/"},"modified":"2026-08-14T17:36:16","modified_gmt":"2026-08-14T17:36:16","slug":"nature-papers-develop-next-generation-patient-derived-models-for-cancer-research-mfcr","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/569011\/","title":{"rendered":"Nature Papers Develop Next-Generation Patient-Derived Models for Cancer Research – MFCR"},"content":{"rendered":"

The Mark Foundation for Cancer Research shared on LinkedIn<\/a>:<\/p>\n

\u201cFor years, scientists have been looking for ways to reduce our reliance on traditional 2D cell lines \u2013 models that often fail to reflect how complex human tumors behave, mutate, and respond to treatment in actual patients.<\/p>\n

A trio of landmark papers published in Nature addresses that challenge head-on.<\/p>\n

An international team of researchers \u2013 including Mark Foundation grantees Rebecca Fitzgerald, Owen Sansom, Isidro Cort\u00e9s Ciriano, Nikhil Joshi, Semir Beyaz, Rameen Beroukhim, Keith Ligon, Andrew Aguirre, James Brenton, Andrea Califano, David Tuveson, Nicolas Robine, and Peter Sorger \u2013 has developed a major suite of open-access resources for the global oncology community.<\/p>\n

Together, these companion papers deliver:<\/p>\n

665 next-generation models spanning 25 cancer types, including rare diseases, backed by extensive clinical and genomic data
\n256 clinically annotated tumor organoids derived directly from colorectal, esophageal, ovarian, pancreatic, and gastric cancer samples
\n147 genome-scale CRISPR screens and deep multi-omic characterizations across 10 cancer types<\/p>\n

These models give researchers a much more realistic starting point for research than standard lab samples.<\/p>\n

Paired with screening data, they offer a powerful new toolkit to uncover new vulnerabilities and develop better-targeted and more effective therapeutics.<\/p>\n

Huge congratulations to all the authors and institutions involved in this massive undertaking.<\/p>\n

We\u2019re inspired to see so many scientists from our grantee community helping drive the kind of open, collaborative science we need to change the future for cancer patients.<\/p>\n

Read the papers in Nature.\u201d<\/p>\n

Title: A compendium of next-generation patient-derived models for diverse cancers<\/p>\n

Authors: Dina ElHarouni, Mushriq Al-Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A. Misek, Heeju Noh, Luca Zanella, Yuen-Yi Tseng, Hayley E. Francies, Dennis Plenker, Cindy W. Kyi, Julyann Perez-Mayoral, Megan J. Stine, Eva Tonsing-Carter, Rachana Agarwal, Jean Claude Zenklusen, James M. Clinton, Jennifer M. Shelton, Timothy R. Chu, William F. Hooper, Xavi Loinaz, Paula Keskula, Jordan Tagle, Peyton C. Kuhlers, Bahar Tercan, Sylvia F. Boj, Alessandro Vasciaveo, Lorenzo Tomassoni, James M. Crawford, Shawna Walsh, Claire Sinai, Sonam Bhatia, Priya Sridevi, Hardik Patel, Maria Antonietta Cerone, The HCMI Network, Kyle Ellrott, Calvin J. Kuo, Olivier Elemento, Semir Beyaz, Vincenzo Corbo, David L. Spector, Rameen Beroukhim, Martin L. Ferguson, Andrew D. Cherniack, Peter W. Laird, Nicolas Robine, Andrew McPherson, Katherine A. Hoadley, Mathew J. Garnett, David A. Tuveson, Andrea Califano, Paul T. Spellman, Keith L. Ligon, Daniela S. Gerhard, Louis M. Staudt, Jesse S. Boehm<\/p>\n

Read the articles<\/a><\/p>\n

Title: A tumour-derived organoid biobank maps cancer gene dependencies<\/p>\n

Authors: C. Herranz-Ors, S. G. Bhosle, A. E. Beck, J. G. R. Gilbert, G. Picco, J. Espejo Valle-Inclan, F. Muyas, S. Valentini, A. E. Andres, R. Ansari, S. Barthorpe, G. Battarbee, C. M. Beaver, S. Brocklesby, J. Cantwell, C. A. Collins, J. Davis, H. G. Dimitrova, J. Doran, E. Efendi, K. Evans, M. Fekry, T. A. Fowler, M. Garcia-Casado, J. A. T. Griffiths, C. Hall, R. Hamer, C. Hardy, Z. Hewitson, E. Hitch, L. Holland, D. A. Jackson, N. Joshi, A. Kavasakali, L. Letchford, H. B. Lightfoot, H. Lingala, I. Mali, K. May, T. Mironenko, J. Morris, C. Pacini, S. Price, G. Robert-Tissot, H. A. Rogers, J. V. Smith, K. Smith, E. Souster, W. J. Spence, F. Thomas, S. F. Vieira, S. Walker, G. Alfonsin, H. Bermingham, H. Coles, D. P. Ennis, A. Freeman, G. Giannone, N. Grehan, E. A. Griffiths, J. Hall, S. L. Lee, E. Y. L. Leung, C. Loreno, C. Millington, A. Mirnezami, B. Nutzinger, K. Orzechowska, C. M. A. Pinna, A. M. Redmond, K. Roberts, S. Roy, D. A. Sanders, P. Taniere, M. Vias, K. Wanigasooriya, OCCAMS Consortium, M. R. Stratton, L. M. Staudt, U. McDermott, J. D. Brenton, I. A. McNeish, A. Biankin, O. J. Sansom, I. Cortes-Ciriano, T. J. Underwood, R. C. Fitzgerald, A. D. Beggs, H. E. Francies, M. J. Garnett<\/p>\n

Read the article<\/a><\/p>\n

Title: A dependency map enhanced with next-generation 3D cancer models<\/p>\n

Authors: James V. Neiswender, Samuel Maffa, Lisa Brenan, Dina ElHarouni, Yejie Yun, Isabella Boyle, Kirsty Wienand, Haider Inam, Tate Bertea, Ashley Anderson, Megan Wong, Matias Enriquez, Evan Lenz, Beatriz Villafranca, Nora Shanks, Mary Hager, Nia Lloyd, Hannah Shadmany, Sarah J. Wie, Harry Liang, Konnor Yunghans, Xiaomeng Zhang, Lauren Golden, Hannah Harris, Serena Day, Philip Montgomery, Samantha Stokes, Ross M. Giglio, Cynthia Hajal, James R. Whittle, Guadalupe Garcia, Caitlin E. Mills, Mehdi Touat, Kristine Pelton, Hongyu Li, Prem Sai Prabhakar, Sonja Herter, Zoe Hoffmann Kamrat, Dan Gui, Julien Dilly, Chen Khuan Wong, Jimmy A. Guo, Sangita Pal, Yossef Baidi, Ryan Johnston, Daniel D. Brown, Sonam Bhatia, Peter S. Winter, Srivatsan Raghavan, Rameen Beroukhim, Eva Colas, David L. Spector, Adam J. Bass, Peter K. Sorger, Yu Chen, Sarah J. Hill, Steffi Oesterreich, Adrian V. Lee, Himisha Beltran, Jesse S. Boehm, Yuen-Yi Tseng, David E. Root, William C. Hahn, Andrew J. Aguirre, Catarina D. Campbell, Keith L. Ligon, Joshua M. Dempster, Tsukasa Shibue, Francisca Vazquez<\/p>\n

Read the article<\/a><\/p>\n

Other articles about MFCR<\/a> on OncoDaily.<\/p>\n","protected":false},"excerpt":{"rendered":"The Mark Foundation for Cancer Research shared on LinkedIn: \u201cFor years, scientists have been looking for ways to…\n","protected":false},"author":2,"featured_media":569012,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[134,111,139,69],"class_list":["post-569011","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-new-zealand","tag-newzealand","tag-nz"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/569011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=569011"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/569011\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/569012"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=569011"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=569011"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=569011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}