{"id":605188,"date":"2026-09-19T10:08:19","date_gmt":"2026-09-19T10:08:19","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/605188\/"},"modified":"2026-09-19T10:08:19","modified_gmt":"2026-09-19T10:08:19","slug":"scientists-transplant-human-brain-cells-into-mice-to-research-disease","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/605188\/","title":{"rendered":"Scientists transplant human brain cells into mice to research disease"},"content":{"rendered":"<p><img alt=\"\" loading=\"lazy\" width=\"485\" height=\"321\" decoding=\"async\" data-nimg=\"1\" class=\"rounded-lg\" style=\"color:transparent\" src=\"https:\/\/www.newsbeep.com\/nz\/wp-content\/uploads\/2026\/09\/https:\/\/media.zenfs.com\/en\/newsnation_articles_600\/07cc00a87a0f2be4bf2682eb1a5e24d0.jpg\"\/><\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">(<a data-ylk=\"slk:NewsNation;elm:context_link;itc:0;sec:content-canvas;\" data-yga=\"{&quot;yLinkElement&quot;:&quot;link&quot;,&quot;yLinkElementType&quot;:&quot;article_link&quot;}\" href=\"https:\/\/www.newsnationnow.com\/\" rel=\"noopener noreferrer nofollow\" target=\"_blank\">NewsNation<\/a>) \u2014 Researchers trying to study human disease conditions have turned to mice by transplanting lab-grown human brain cells into the small rodents.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">The study, published in the journal <a data-ylk=\"slk:Nature;elm:context_link;itc:0;sec:content-canvas;\" data-yga=\"{&quot;yLinkElement&quot;:&quot;link&quot;,&quot;yLinkElementType&quot;:&quot;article_link&quot;}\" href=\"https:\/\/www.nature.com\/articles\/s41586-026-11032-2\" rel=\"noopener noreferrer nofollow\" target=\"_blank\">Nature<\/a>, found that the human neurons successfully integrated into the animals&#8217; brains. Researchers said the mice were engineered to be born without a cortex or hippocampus, allowing space for the brain cells to grow inside.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">&#8220;For the past two decades, there&#8217;s been a quest to try to build models of the human brain outside of the human body,&#8221; says Dr. Sergiu Pa\u0219ca, a professor at Stanford University. &#8220;This is not going to replace all the models we had before, but it&#8217;s going to provide us access to other aspects of human brain function that would be very difficult to study otherwise.&#8221;<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\"><a data-ylk=\"slk:&#039;Wolverine&#039; peptide claims to accelerate healing and recovery;elm:context_link;itc:0;sec:content-canvas;\" data-yga=\"{&quot;yLinkElement&quot;:&quot;link&quot;,&quot;yLinkElementType&quot;:&quot;article_link&quot;}\" href=\"https:\/\/www.newsnationnow.com\/health\/wolverine-peptide-claims-accelerate-healing-recovery\/?ipid=promo-link-block1\" class=\"promo-link__link\" rel=\"noopener noreferrer nofollow\" target=\"_blank\">\u00a0&#8216;Wolverine&#8217; peptide claims to accelerate healing and recovery\u00a0<\/a><\/p>\n<p>Researchers injected human organoids into engineered mice<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">To conduct their analysis, Pasca and his team spent years creating the mice to establish better scientific models for researching neurodegenerative disease. The decision to experiment on mice came after <a data-ylk=\"slk:previous studies;elm:context_link;itc:0;sec:content-canvas;\" data-yga=\"{&quot;yLinkElement&quot;:&quot;link&quot;,&quot;yLinkElementType&quot;:&quot;article_link&quot;}\" href=\"https:\/\/www.nytimes.com\/2026\/09\/16\/science\/human-mouse-brains-organoids.html\" rel=\"noopener noreferrer nofollow\" target=\"_blank\">previous studies<\/a> on human organoids to observe the early stages of brain development.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">The organoids flourished in the bred mice, feeding on the skull&#8217;s fluid before connecting to the blood vessels in the brain. As a result, the mice&#8217;s human neurons expanded to nearly 4 million.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\"><a data-ylk=\"slk:Compounded skin supplement could be deadly, recalled by pharmacy;elm:context_link;itc:0;sec:content-canvas;\" data-yga=\"{&quot;yLinkElement&quot;:&quot;link&quot;,&quot;yLinkElementType&quot;:&quot;article_link&quot;}\" href=\"https:\/\/www.newsnationnow.com\/health\/third-pharmacy-recall-glutathione\/?ipid=promo-link-block2\" class=\"promo-link__link\" rel=\"noopener noreferrer nofollow\" target=\"_blank\">\u00a0Compounded skin supplement could be deadly, recalled by pharmacy\u00a0<\/a><\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">&#8220;They actually have quite good locomotion,&#8221; Pa\u0219ca <a data-ylk=\"slk:noted;elm:context_link;itc:0;sec:content-canvas;\" data-yga=\"{&quot;yLinkElement&quot;:&quot;link&quot;,&quot;yLinkElementType&quot;:&quot;article_link&quot;}\" href=\"https:\/\/www.npr.org\/2026\/09\/16\/nx-s1-5968873\/lab-mouse-human-brain-cells-organoid-disease-ethics\" rel=\"noopener noreferrer nofollow\" target=\"_blank\">noted<\/a>. &#8220;They don&#8217;t do that well in memory tasks, but you wouldn&#8217;t be able to tell when you look at these animals that they&#8217;re lacking half of the volume of their brain.&#8221;<\/p>\n<p>Researchers exposed mice to low oxygen for hours<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">To clarify how the vermin could provide answers on brain disorders, some of the mice were <a data-ylk=\"slk:exposed to;elm:context_link;itc:0;sec:content-canvas;\" data-yga=\"{&quot;yLinkElement&quot;:&quot;link&quot;,&quot;yLinkElementType&quot;:&quot;article_link&quot;}\" href=\"https:\/\/www.theguardian.com\/science\/2026\/sep\/16\/mice-part-human-brains-research\" rel=\"noopener noreferrer nofollow\" target=\"_blank\">exposed to<\/a> low oxygen for hours.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\"><a data-ylk=\"slk:Second death confirmed in Bronx Legionnaires&#039; disease cluster;elm:context_link;itc:0;sec:content-canvas;\" data-yga=\"{&quot;yLinkElement&quot;:&quot;link&quot;,&quot;yLinkElementType&quot;:&quot;article_link&quot;}\" href=\"https:\/\/www.newsnationnow.com\/health\/second-death-bronx-legionnaires-disease-cluster\/?ipid=promo-link-block3\" class=\"promo-link__link\" rel=\"noopener noreferrer nofollow\" target=\"_blank\">\u00a0Second death confirmed in Bronx Legionnaires&#8217; disease cluster\u00a0<\/a><\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">Researchers discovered the human brain tissue in the mice comprised of rare cells, von Economo neurons. Von Economo neurons are among the first to succumb in frontotemporal dementia. The low oxygen resulted in the mice having trouble walking.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">&#8220;We&#8217;re trying to see whether mutations that are associated with frontotemporal dementia are making the cells uniquely susceptible to disease,&#8221; Pa\u0219ca explained. &#8220;And why? Why is this happening?&#8221;<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">Researchers suggest the transplant could revolutionize the study of conditions such as Alzheimer&#8217;s disease, autism, epilepsy and schizophrenia by allowing scientists to observe human brain cells functioning inside a living brain.<\/p>\n<p class=\"mb-4 text-lg md:leading-8 break-words\">Copyright 2026 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.<a data-ylk=\"slk:For the latest news, weather, sports, and streaming video, head to NewsNation.;elm:context_link;itc:0;sec:content-canvas;\" data-yga=\"{&quot;yLinkElement&quot;:&quot;link&quot;,&quot;yLinkElementType&quot;:&quot;article_link&quot;}\" href=\"https:\/\/www.newsnationnow.com\" rel=\"noopener noreferrer nofollow\" target=\"_blank\">For the latest news, weather, sports, and streaming video, head to NewsNation.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"(NewsNation) \u2014 Researchers trying to study human disease conditions have turned to mice by transplanting lab-grown human brain&hellip;\n","protected":false},"author":2,"featured_media":605189,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[298231,26382,15464,134,7299,182145,58765,111,139,69,2214,35760],"class_list":["post-605188","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-blood-vessels-in-the-brain","tag-brain-cells","tag-brain-development","tag-health","tag-human-brain","tag-human-neurons","tag-mice","tag-new-zealand","tag-newzealand","tag-nz","tag-researchers","tag-stanford-university"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/605188","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=605188"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/605188\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/605189"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=605188"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=605188"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=605188"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}