{"id":610283,"date":"2026-09-24T12:42:08","date_gmt":"2026-09-24T12:42:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/610283\/"},"modified":"2026-09-24T12:42:08","modified_gmt":"2026-09-24T12:42:08","slug":"down-syndrome-moyamoya-linked-to-delayed-diagnosis-and-stroke","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/610283\/","title":{"rendered":"Down Syndrome Moyamoya Linked to Delayed Diagnosis and Stroke"},"content":{"rendered":"

In a retrospective cohort study published in\u00a0Stroke<\/a>,\u00a0Jonathan D. Santoro, MD, of Children\u2019s Hospital in Los Angeles, California, and colleagues, compared data from 198 children with DS\u2013associated moyamoya syndrome (DS-MMS; n=77) and MMS without DS (n=121).<\/p>\n

The primary outcome was stroke as the primary presenting symptom. This was more common in DS-MMS (71.4% versus 20.7%; absolute difference, 50.8%), with an adjusted odds ratio (aOR) of 14.50;\u00a0P<0.001.<\/p>\n

Secondary outcomes included diagnostic delays, angiographic features, prediagnostic systolic blood pressure percentiles, and 1-year neurological outcomes. Results showed greater diagnostic delay in children with DS-MMS, both from symptom onset to presentation and from presentation to diagnostic confirmation (both\u00a0P<0.001). Posterior circulation involvement was also more common in children with DS-MMS (aOR, 2.18;\u00a0P=0.03), though angiographic severity was similar between groups.<\/p>\n

When evaluating prediagnostic systolic blood pressure, blood pressure elevation was significantly higher in the DS-MMS group at 12 months (P=0.001) and 6 months (P<0.001), but not at 24 months (P=0.15) or 18 months (P=0.10). DS-MMS was also associated with worse 1-year neurological outcomes, including greater disability (adjusted odds ratio, 2.58;\u00a0P<0.001) and spasticity (aOR, 6.33;\u00a0P<0.001).<\/p>\n

Overall, results indicate that DS-MMS is a high-risk phenotype linked with delayed recognition and greater likelihood of stroke at presentation. As the authors note, these findings support targeted early detection strategies for children with DS-MMS to address the overall worse outcomes experienced by this population.<\/p>\n","protected":false},"excerpt":{"rendered":"In a retrospective cohort study published in\u00a0Stroke,\u00a0Jonathan D. Santoro, MD, of Children\u2019s Hospital in Los Angeles, California, and…\n","protected":false},"author":2,"featured_media":610284,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[134,111,139,69],"class_list":["post-610283","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-new-zealand","tag-newzealand","tag-nz"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/610283","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=610283"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/610283\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/610284"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=610283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=610283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=610283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}