Participants had a median age of 71 and received either 720 \u00b5g\/day of vitamin K2 MK-7 plus 25 \u00b5g\/day of vitamin D3 or placebo for 24 months.<\/p>\n
The mean increase in CAC was 196 Agatston units (AU) in the vitamin group compared with 248 AU in the placebo group, representing a between-group difference of 52 AU.<\/p>\n
The effect was consistent across sex and baseline CAC categories. A subgroup undergoing coronary CT angiography also showed attenuated progression of calcified plaque, without an increase in non-calcified plaque volume.<\/p>\n
The researchers said the findings support the hypothesis that targeting vitamin K-dependent pathways may influence coronary calcification, but they noted that further research is still needed to determine whether this translates into reductions in cardiovascular events.<\/p>\n
Implications for vitamin K2 formulations<\/p>\n
The trial used Balchem’s K2VITAL DELTA, a microencapsulated vitamin K2 MK-7 ingredient.<\/p>\n
The company says the ingredient uses double-coated beadlets designed to improve K2 stability in formulations containing minerals such as calcium and magnesium, plus is suitable for formats including powders, tablets, gummies and water-based liquids.<\/p>\n
Balchem added that it has also invested in quality testing around vitamin K2, reporting that its K2VITAL portfolio typically contains 99.8% all-trans MK-7.<\/p>\n
The company says independent testing of 38 commercially available K2 products found that 29% met its criteria for both MK-7 content and isomeric purity, highlighting formulation quality and stability as important considerations for manufacturers.<\/p>\n
The DANCODE findings build on earlier research from the Danish group, including the AVADEC trial<\/a>, and add to the evidence base being developed around vitamin K2 MK-7, cardiovascular health and healthy ageing.<\/p>\n
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