{"id":615032,"date":"2026-09-29T05:36:08","date_gmt":"2026-09-29T05:36:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/615032\/"},"modified":"2026-09-29T05:36:08","modified_gmt":"2026-09-29T05:36:08","slug":"organoids-missing-the-tsc2-gene-form-rogue-astrocytes-and-more","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/615032\/","title":{"rendered":"Organoids missing the TSC2 gene form rogue astrocytes; and more"},"content":{"rendered":"<p>Two roads diverge: Human brain organoids missing the gene TSC2 have overreactive astrocytes that are similar to those found in tubers from people with tuberous sclerosis complex, according to a new <a href=\"https:\/\/doi.org\/10.1038\/s41586-026-11054-w\" target=\"_blank\" rel=\"nofollow noopener\">study<\/a>. The findings substantiate the idea that glial pathology results from altered protein expression and activity\u2014specifically, high mTORC1 signaling\u2014rather than from seizures themselves. \u201cThese results implicate glial dysfunction as a driver of TSC pathogenesis and highlight reactive astrocytes as potential therapeutic targets for TSC-related neuropathology,\u201d the investigators write.<\/p>\n<p>Autism research spotted this week:<\/p>\n<p>\u201cPostnatal maturation of putamen microstructure accompanies topographic white matter connectivity and altered circuits in autism\u201d <a href=\"https:\/\/doi.org\/10.64898\/2026.09.09.750447\" target=\"_blank\" rel=\"nofollow noopener\">bioRxiv<\/a><br \/>\n\u201cA retinoic acid autoregulatory loop governing prefrontal-motor arealization\u201d <a href=\"https:\/\/doi.org\/10.1038\/s41586-026-11014-4\" target=\"_blank\" rel=\"nofollow noopener\">Nature<\/a><br \/>\n\u201cDevelopmental cerebellar pathology in mouse models of SCN2A premature termination codon variants\u201d <a href=\"https:\/\/doi.org\/10.64898\/2026.09.13.751275\" target=\"_blank\" rel=\"nofollow noopener\">bioRxiv<\/a><br \/>\n\u201cMaternal-fetal immune conflict contributes to male-specific impairments in a mouse model of neurodevelopmental disorders\u201d <a href=\"https:\/\/doi.org\/10.1126\/sciadv.aeg0779\" target=\"_blank\" rel=\"nofollow noopener\">Science Advances<\/a><br \/>See also: \u201c<a href=\"https:\/\/www.thetransmitter.org\/spectrum\/post-infection-immune-conflict-alters-fetal-development-in-some-male-mice\/\" rel=\"nofollow noopener\" target=\"_blank\">Post-infection immune conflict alters fetal development in some male mice<\/a>\u201d<br \/>\n\u201cParvalbumin interneurons and dentate gyrus homeostatic dysregulation shape epileptogenesis in Angelman syndrome model mice\u201d <a href=\"https:\/\/doi.org\/10.64898\/2026.09.17.752419\" target=\"_blank\" rel=\"nofollow noopener\">bioRxiv<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Two roads diverge: Human brain organoids missing the gene TSC2 have overreactive astrocytes that are similar to those&hellip;\n","protected":false},"author":2,"featured_media":615033,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[134,111,139,69],"class_list":["post-615032","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-new-zealand","tag-newzealand","tag-nz"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/615032","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=615032"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/615032\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/615033"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=615032"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=615032"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=615032"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}