{"id":633748,"date":"2026-10-17T20:50:08","date_gmt":"2026-10-17T20:50:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/633748\/"},"modified":"2026-10-17T20:50:08","modified_gmt":"2026-10-17T20:50:08","slug":"wits-university-hiv-finds-escape-routes-from-preventive-antibody-but-newer-antibodies-may-close-them","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/633748\/","title":{"rendered":"Wits University | HIV finds escape routes from preventive antibody \u2013 but newer antibodies may close them"},"content":{"rendered":"<p>Wits University news release<\/p>\n<p>In a landmark HIV prevention trial, an antibody blocked viruses most vulnerable to it, but others broke through. Now researchers have uncovered how HIV evolved after those infections \u2013 and why the amount of antibody in the body is an essential part of the story.<\/p>\n<p>The Antibody-Mediated Prevention (AMP) trials enrolled more than 4,600 volunteers across Africa, the Americas, and Europe to test VRC01, a laboratory-made broadly neutralising antibody (bnAb).<\/p>\n<p>In the AMP trial, VRC01 did not significantly reduce HIV infections overall, although it reduced infections caused by highly sensitive strains by about 75%. \u00a0This study showed that HIV requires high antibody titers, and it illustrates the importance of maintaining those titers throughout the dosing cycle.<\/p>\n<p>A new study published in <a href=\"https:\/\/www.nature.com\/articles\/s41564-026-02467-4\" target=\"_blank\" rel=\"noopener nofollow\">Nature Microbiology<\/a> has now examined what happened after infection in people who received VRC01. The findings show how a virus can respond to antibody pressure \u2013 and offer clues for improving future antibodies and vaccines.<\/p>\n<p>Read the full news release <a href=\"https:\/\/www.wits.ac.za\/news\/latest-news\/research-news\/2026\/2026-10\/hiv-finds-escape-routes-from-preventive-antibody--but-newer-antibodies-may-close-them.html\" target=\"_blank\" rel=\"noopener nofollow\">here<\/a>.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"Wits University news release In a landmark HIV prevention trial, an antibody blocked viruses most vulnerable to it,&hellip;\n","protected":false},"author":2,"featured_media":633749,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[134,111,139,69],"class_list":["post-633748","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-new-zealand","tag-newzealand","tag-nz"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/633748","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=633748"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/633748\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/633749"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=633748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=633748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=633748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}