{"id":640153,"date":"2026-10-24T17:22:15","date_gmt":"2026-10-24T17:22:15","guid":{"rendered":"https:\/\/www.newsbeep.com\/nz\/640153\/"},"modified":"2026-10-24T17:22:15","modified_gmt":"2026-10-24T17:22:15","slug":"remote-ischemic-conditioning-in-pulmonary-fibrosis","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/nz\/640153\/","title":{"rendered":"Remote Ischemic Conditioning in Pulmonary Fibrosis"},"content":{"rendered":"

REMOTE ischemic conditioning significantly reduced pulmonary fibrosis<\/a> pathology in a diesel exhaust-induced mouse model, improving physiological measures, lowering inflammatory and fibrotic markers, and restoring mitochondrial health.\u00a0<\/p>\n

These findings suggest that this non-pharmacological intervention could have therapeutic potential in pulmonary fibrosis.\u00a0<\/p>\n

Remote Ischemic Conditioning in Mice\u00a0<\/p>\n

Researchers evaluated remote ischemic conditioning<\/a> in mice with pulmonary fibrosis induced by prolonged diesel exhaust exposure.\u00a0<\/p>\n

The intervention was delivered either before or during disease development and was compared with both untreated disease and treatment with pirfenidone.\u00a0<\/p>\n

Across multiple physiological and molecular assessments, mice receiving remote ischemic conditioning demonstrated clear improvements compared with untreated animals.\u00a0<\/p>\n

Body weight and heart rate variability, both adversely affected by diesel exhaust exposure, improved in groups receiving the intervention.\u00a0\u00a0<\/p>\n

Histopathological analysis also revealed reduced cellular infiltration, less bronchiolar inflammation, and fewer structural abnormalities within lung tissue.\u00a0\u00a0<\/p>\n

These changes indicated attenuation of key pulmonary fibrosis features.\u00a0<\/p>\n

Inflammation and Fibrotic Markers Decline\u00a0<\/p>\n

The therapeutic benefits of remote ischemic conditioning were also reflected in circulating biomarkers associated with pulmonary fibrosis.\u00a0\u00a0<\/p>\n

Mice receiving the intervention showed significantly lower levels of actin alpha 2 smooth muscle, brain natriuretic peptide, surfactant protein-D, Krebs von den Lungen-6, and collagen type 1 alpha 1 compared with untreated animals.\u00a0<\/p>\n

Evaluation of bronchoalveolar lavage fluid demonstrated reduced inflammatory activity.\u00a0\u00a0<\/p>\n

Total leukocyte counts were lower in treated groups, while concentrations of interleukin-1\u03b2, interleukin-13, and interleukin-17A were significantly decreased.\u00a0\u00a0<\/p>\n

Together, these findings suggest that the intervention alleviated inflammatory processes linked to fibrosis progression.\u00a0<\/p>\n

Researchers also observed improvements in mitochondrial function.\u00a0\u00a0<\/p>\n

Treated mice exhibited higher mitochondrial membrane potential and lower cellular reactive oxygen species levels, indicating healthier mitochondrial activity and reduced oxidative stress.\u00a0<\/p>\n

Transcriptomic Findings Support Therapeutic Effect\u00a0<\/p>\n

Transcriptomic analysis provided further evidence supporting the intervention.\u00a0\u00a0<\/p>\n

Lung tissue from mice receiving remote ischemic conditioning showed downregulation of multiple pulmonary fibrosis-associated pathways related to immune regulation, extracellular matrix organisation, connective tissue development, and cellular bioenergetics.\u00a0<\/p>\n

Several pulmonary fibrosis-related genes were suppressed in treated groups, while genes associated with tissue recovery and pulmonary health were upregulated.\u00a0\u00a0<\/p>\n

The researchers also identified several potential fibrosis-associated markers, including Calhm6, Hrc, Dnase1l3, Pla2g2d, Stab2, and Timd4, which may contribute to future investigations into disease mechanisms and treatment response.\u00a0<\/p>\n

Notably, the combination of remote ischemic conditioning with pirfenidone produced the lowest overall fibrotic burden across treatment groups.\u00a0\u00a0<\/p>\n

The researchers concluded that remote ischemic conditioning may represent a promising adjunctive strategy for pulmonary fibrosis and warrants further translational research.\u00a0<\/p>\n

Reference\u00a0<\/p>\n

Kumari S et al. Remote ischemic conditioning mitigates diesel exhaust-induced pulmonary fibrosis by alleviating pulmonary inflammation and fibrogenesis. Sci Rep. 2026;DOI:10.1038\/s41598-026-72674-w.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"REMOTE ischemic conditioning significantly reduced pulmonary fibrosis pathology in a diesel exhaust-induced mouse model, improving physiological measures, lowering…\n","protected":false},"author":2,"featured_media":640154,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[134,111,139,69],"class_list":["post-640153","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-new-zealand","tag-newzealand","tag-nz"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/640153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=640153"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/640153\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/640154"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=640153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=640153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=640153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}