A team of researchers from China conducted the study and published their findings in the International Journal of Dermatology.<\/p>\n
The investigators explained that some patients with plaque psoriasis experience a reduction in therapeutic efficacy after they discontinue treatment with a biologic. The goal of their post hoc analysis was to uncover potential predictors of efficacy maintenance among patients with the disease who discontinued treatment with vunakizumab.<\/p>\n
Data from a phase 3 trial exploring the efficacy and safety of vunakizumab in patients with moderate-to-severe chronic plaque psoriasis were used to inform the analysis. The phase 3 trial included 291 patients with moderate-to-severe plaque psoriasis, and all enrolled participants had \u201cachieved 100% improvement in Psoriasis Area and Severity Index (PASI) score at Week 52.\u201d<\/p>\n
For the purpose of the analysis, the investigators defined efficacy maintenance as a maintained PASI score of 90 or 100 at 20 weeks after patients had discontinued vunakizumab.<\/p>\n
The results of the analysis revealed that the rates of PASI 90 and PASI 100 maintenance at 20 weeks after vunakizumab had been discontinued were 72.5% and 44.7%, respectively. A multivariate logistic regression model demonstrated that treatment interruption (odds ratio [OR],\u2009 0.550; P=0.020) and BMI (OR,\u20090.922; P=0.024) \u201cwere independently associated with a lower possibility of PASI 100 maintenance.\u201d<\/p>\n
However, the investigators pointed out that \u201cthe association of family history of psoriasis and the first time of PASI 100 achievement with PASI 100 maintenance did not achieve statistical significance.\u201d<\/p>\n
Regarding the possibility of PASI 90 maintenance, the investigators found that treatment interruption (OR, 0.257; P<0.001) and psoriasis duration (OR,\u20090.972; P=0.049) were both independently correlated with a reduced likelihood of maintenance. The investigators created two predictive nomograms for PASI 90 and PASI 100 maintenance based on the multivariate logistic regression models, which they reported \u201cdisclosed good calibration performance.\u201d<\/p>\n
Based on their findings, the investigators concluded that BMI, psoriasis duration, and treatment interruption were predictive of inferior efficacy maintenance after patients with moderate-to-severe plaque psoriasis had discontinued vunakizumab.<\/p>\n","protected":false},"excerpt":{"rendered":"A team of researchers from China conducted the study and published their findings in the International Journal of…\n","protected":false},"author":2,"featured_media":646200,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[134,111,139,69],"class_list":["post-646199","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-new-zealand","tag-newzealand","tag-nz"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/646199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/comments?post=646199"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/posts\/646199\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media\/646200"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/media?parent=646199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/categories?post=646199"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/nz\/wp-json\/wp\/v2\/tags?post=646199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}