Novo Nordisk Stock Slumps After Ozempic Pill Fails in Alzheimer’s Trials
Novo Nordisk NOVO.B 3.80%increase; green up pointing triangle shares fell sharply after the Danish drugmaker said a pill…
Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
Mice and drug treatments All mouse experiments were approved by CSHL Internal Animal Care and Use Committee (protocol…
Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli
Bacterial strains and growth conditionsBacterial strains The following strains were from the Keio collection1 (Horizon Discovery): E. coli…
Clonal hematopoiesis in apparent treatment-resistant hypertension, insights from multiple medical centers and community-based cohorts
Kanagal-Shamanna, R., Beck, D. B. & Calvo, K. R. Clonal hematopoiesis, inflammation, and hematologic malignancy. Annu. Rev. Pathol.…
Food-induced phenotypic plasticity in echinoid larvae is inducible and reversible throughout development | BMC Biology
Adult sand dollar collection and spawning Adults of Dendraster excentricus were collected from San Pedro, CA, USA (33°42′…
Piperine suppresses M1 phenotype and induces indoleamine 2,3-dioxygenase gene in LPS-stimulated murine macrophage cell line | BMC Research Notes
Reagents RPMI-1640 medium and fetal bovine serum (FBS) were from Gibco (USA). Sigma-Aldrich (USA) supplied trypan blue, MTT,…
Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries
Livingston, G. et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet 404,…
Metabolome-driven microbiome assembly in ginger (Zingiber officinale) enhances nutrient cycling and crop yield through keystone taxa
Overview of sequencing and De Novo assembly We analysed 36 composite samples from two cultivars with contrasting yields…
US pharma to abandon UK unless NHS pays more, says Trump’s ambassador – POLITICO
The U.K. is locked in drug-pricing negotiations with the Trump administration and pharmaceutical firms about how much the…
Adaptive ER stress promotes mitochondrial remodelling and longevity through PERK-dependent MERCS assembly
PERK promotes myogenesis in myoblasts subjected to physiological levels of ER stressors To investigate the role of adaptive…
L-citrulline protects testicular Sertoli cell function by mitigating DNA damage via the gut-testis axis of sheep fed a high-concentrate diet
Animals Three-month-old sheep were housed in controlled environmental conditions and divided into two groups. One group of ten…
Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor
O’Donnell, M., Langston, L. & Stillman, B. Principles and concepts of DNA replication in bacteria, archaea, and eukarya.…