Dual regulatory role of natural killer T cells during development of hepatocellular carcinoma
The number of iNKT cells decreased in a mouse model of HCC To understand the function of iNKT…
A Carnian theropod with unexpectedly derived features during the first dinosaur radiation
Nesbitt, S. J. et al. Ecologically distinct dinosaurian sister group shows early diversification of Ornithodira. Nature 464, 95–98…
Polymyxin B lethality requires energy-dependent outer membrane disruption
Fanous, J. et al. Limited impact of Salmonella stress and persisters on antibiotic clearance. Nature https://doi.org/10.1038/s41586-024-08506-6 (2025). Article …
Merck KGaA & Siemens Deepen Partnership to Accelerate AI Drug Discovery & Development
About the Life Science business of Merck KGaA, Darmstadt, Germany The Life Science business of Merck KGaA, Darmstadt,…
Oxaloacetate sensing promotes innate immune antiviral defence against influenza virus infection
Saravia, J., Raynor, J. L., Chapman, N. M., Lim, S. A. & Chi, H. Signaling networks in immunometabolism.…
Food insecurity impacts neuroblastoma pathogenesis in murine xenograft tumor models
Cell lines IMR-32 cells were obtained from ATCC in March 2023. Cells were maintained in minimal essential medium,…
Systematic review and meta-analysis of educational approaches to reduce cognitive biases among students
Beyth-Marom, R., Fischhoff, B., Quadrel, M. J. & Furby, L. in Teaching Decision Making to Adolescents (eds Baron,…
Household- and school-level parental education and academic self-concept development in elementary school
UNICEF. An Unfair Start: Inequality in Children’s Education in Rich Countries. https://www.unicef.org/innocenti/reports/an-unfair-start (2019). OECD. Improving Early Equity. https://www.oecd.org/en/publications/2022/10/improving-early-equity_ca4e10f4.html…
Twenty years of tuberculosis-driven selection shaped the evolution of the meerkat major histocompatibility complex
Fijarczyk, A. & Babik, W. Detecting balancing selection in genomes: limits and prospects. Mol. Ecol. 24, 3529–3545 (2015).…
NAD+-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos
Telomere shortening, DNA damage and elevated oxidative stress in blastocysts cultured in vitro Figure 1a depicts the morphology of…
Targeting STING to disrupt macrophage-mediated adhesion in encapsulating peritoneal sclerosis
Establishing a mouse model of EPS with rapid intra-abdominal adhesions We aimed to develop a novel and more…
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment
Fischer, K. et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109, 3812–3819…