Human brain cells transplanted into mice in ‘most extensive’ integration ever
Human brain tissue transplanted into mice that lack a key part of their brains can grow to occupy…
Developmental xenocortication using human-derived organoids in mice
Genetically encoded cortical depletion Emx1-cre (JAX, B6.129S2-Emx1tm1(cre)Krj/J), Esco2fl/fl (JAX, B6N.129S-Esco2tm1.1Ge/J) and C57BL SCID (JAX, B6.Cg-Prkdcscid/SzJ) mice were used…
Israeli startup looks to harness AI to decode the ‘language’ of the brain
If the brain is our most important organ, why do most brain disorders such as depression and post-traumatic…
AI Will Never Be Conscious
The Blake Lemoine incident is remembered today as a high‑water mark of AI hype. It thrust the whole…
Parkinson’s disease as a somato-cognitive action network disorder
Participants In this study, we used 11 independent datasets comprising 863 total participants after quality control. These datasets…
Jellyfish sleep like humans — even though they don’t have brains
The upside-down jellyfish Cassiopea andromeda sleeps for roughly 8 hours a day.Credit: Shahar Shabtai/Alamy Neither jellyfish nor sea…
Will blockbuster obesity drugs revolutionize addiction treatment?
Last April, neuroscientist Sue Grigson received an e-mail from a man detailing his years-long struggle to kick addiction…
Alzheimer’s decline slows with just a few thousand steps a day
Cognition deteriorates less rapidly in people with Alzheimer’s disease who take at least 3,000 to 5,000 steps per…
Disconnecting part of the brain sends it into a deep sleep
Surgically severing part of the brain can send the area into a deep sleep.Credit: Peter Cade/Getty Slow, sleep-like…
Vamp8 modulates cerebral ischemia-reperfusion injury via the autophagy-lysosome pathway
Data download The rat cerebral ischemia-reperfusion injury(CIRI) data were downloaded from the GEO database (https://www.ncbi.nlm.nih.gov/geo/) using the R…
Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, Fifth Edition. Arlington, VA: American Psychiatric Publishing, Inc;…
Cell membrane cholesterol affects serotonin transporter efflux due to altered transporter oligomerization
Material [3H]5-HT (43.1 µCI mmol−1), [3H]dopamine (51.4 µCI mmol−1), [3H]nisoxetine (46.0 µCI mmol−1), [3H]WIN35428 (CFT) (82.6 µCI mmol−1), and Ultima GoldTM XR…