Ms Hughes said she wants to bring “important stories” to Belfast – stories she is “proud to tell and be associated with”.
She grew up in west Belfast in the 1970s and 1980s, before leaving for the USA to pursue an acting career.
“I’m really happy to be back at the Lyric Theatre,” she told BBC News NI.
“Belfast is special. Belfast is the best city.
“I travel for work, I go to many different places, and Belfast is the greatest audiences, the most hospitable and welcoming and responsive audiences, and the Lyric team are fantastic.
“I love being here. It’s a beautiful space.”