Proton pump inhibitors (PPIs), such as omeprazole, should be avoided, according to Dr. Punam Krishan, a practicing NHS general practitioner and the resident physician on BBC’s Morning Live.Charlotte Smith Senior Lifestyle Content Editor, Sarah Tulloch Senior Lifestyle and Features Reporter and Ambarish Awale
17:58, 29 Oct 2025
(Image: Getty Images)
A BBC Morning Live doctor has issued an urgent warning to anyone taking omeprazole – highlighting one crucial red flag symptom that shouldn’t be ignored.
Around a quarter of UK adults experience acid reflux, with many suffering from it occasionally, often following a heavy meal.
People who regularly deal with the uncomfortable condition may be given PPIs such as omeprazole to control symptoms. But Dr Punam has revealed why those on this medication must be careful, particularly during long-term use, stressing the importance of routine medical monitoring.
Dr Punam, a practising NHS GP, serves as the resident doctor on BBC’s Morning Live whilst also working as a media medic, health broadcaster, and children’s book author.
(Image: BBC Morning Live)
Speaking to Morning Live presenters Gethin Jones and Helen Skelton, the medical expert began her warning by outlining what acid reflux involves. She said: “Acid reflux is all about what happens in your stomach. So we all have acid in our stomach and it has a very important role. The role of that is to break down and digest the food. Now, at the top of the stomach, we have a little valve, a sphincter, and it acts like a trapdoor.”, reports the Mirror.
“And its job is to basically seal the contents so the acid is not essentially tracking back up the food pipe, your oesophagus. However, if that sphincter, that valve, becomes too loose, it can become very relaxed by things like heavy meals.
“If you’ve had alcohol, if you lie down straight after having a heavy meal, that can actually mean that that acid from the stomach can end up creeping back up the food pipe and cause that heavy pressured burning sensation that people get.”
Host Gethin asked: “What about the most common ways to treat it then?”.
Dr Punam said: “So there are lots of different things that we can do. If, of course, you’re having it just every now and then, then lots of people do get antacids or basically medications like alginates. Examples of that include Gaviscon. And these basically help to just kind of neutralise the acid. They’re very effective and you can just use them as and when needed.
“However, if the discomfort is persistent, we often prescribe proton pump inhibitors, PPIs for short. Examples of these are omeprazole, lansoprazole. And these are incredible and have really transformed the way that we treat acid reflux. They essentially help to treat the acid production at the source.”
The NHS doctor gave a stark warning to anyone using PPIs, explaining: “Essentially these medications aren’t there to be used unnecessarily or for a long period of time. They do require us to review them. And that’s because if used over a long period of time, they can slightly increase your risk of things like low magnesium, low vitamin B12, but also increase the risk of gut infections, particularly Clostridioides difficile. We call that C. diff for short.”
(Image: Getty)
Dr Punam highlighted the importance of routine monitoring for anyone taking PPIs long-term, explaining: “Now, we have this bacteria in our bowel, you and I, we all have it, and it lives in balance. However, medications like PPIs can tip that balance. And if you get overgrowth of this bacterium, it can cause persistent diarrhoea. That is a red flag.
“So you do need to speak to your doctor if that is an issue and you suddenly start developing diarrhoea. Or if you’ve got a change in bowel habit, we always say check in with your doctor. Just make sure that you are getting those reviews with your GP.”
Helen questioned: “I guess the trouble is if it works, you stick with it, don’t you?” Dr Punam confirmed: “Yeah, it is.”
Gethin then remarked: “But you don’t even know how long you’re taking it for in the end, are you?” Dr Punam answered: “Well, that’s just it. Sometimes you can just be taking it, and the problem is resolved, but you’re just taking the medication. So do go in for your regular reviews.”
How frequently should people on PPIs see their doctor?
If you are using omeprazole over the counter, avoid taking it for more than a fortnight. You should consult a GP if: If your GP has prescribed omeprazole for long-term use, they should keep you under regular observation.
Your GP should arrange follow-up appointments based on your individual health needs and risk factors, for instance, every six to 12 months. If your GP recommends omeprazole for more than a year, it’s crucial to have routine check-ups to minimise the risk of developing long-term side effects.
What are the symptoms to watch out for?
Symptoms of low magnesium include muscle cramps, fatigue, and an irregular heartbeat, along with less specific symptoms like loss of appetite, nausea, and weakness. More severe deficiencies can lead to numbness, tingling, personality changes, seizures, and abnormal heart rhythms.
Signs of low vitamin B12 include fatigue, weakness, pale skin, and a sore or swollen red tongue. Other symptoms can include neurological issues like pins and needles, difficulty with balance, and memory problems, as well as shortness of breath, heart palpitations, and digestive problems.
Symptoms of a C. diff gut infection are watery diarrhoea, stomach cramps and pain, a high temperature (fever), nausea, loss of appetite, and dehydration.
In serious cases, complications can develop, such as life-threatening inflammation of the intestines.
What tests can be done to check?
Helen asked: “What if you want to do something without medication? Can you ease the symptoms without taking any meds?”. The NHS GP explained: “So if you have got symptoms that have not settled despite you trying to manage them, then it is important to check in with your GP because we would want to investigate that further.
“Ultimately, you want to find out what is the root cause of this and is it something more serious? We would do tests like checking for a bacterium called Helicobacter pylori, which increases the production of acid. We may refer you for a gastroscopy. This is a camera test that goes into the stomach to see is there any inflammation, any ulcers, anything more serious.”
Dr Punam then shared information about a groundbreaking new diagnostic procedure.
“There is a really exciting pilot at the moment that is being tried out by the NHS across pharmacies in England,” she said.
“And it is to try to identify any early changes that could increase your risk of oesophageal cancer. It’s called the sponge on a string test. And it involves putting a tiny capsule that’s attached to a thread down through the mouth into the stomach. It opens up like a tiny little sponge. It takes little cells from the stomach and the lining of your food pipe, your oesophagus. We pull it back out, and essentially, it’s easy if any cellular changes have happened. This is fantastic. If it is successful and it gets rolled out, we could pick up changes much earlier on.”
What other options can offer relief besides medication?
Dr Punam suggested: “At the end of the day, medications are great, but there’s lots of things that we can do every day in our lifestyles that make a massive, massive difference. The first thing is if you are struggling with heartburn, indigestion, acid reflux, then eat smaller portions.
“If you eat big, heavy meals, you can actually put a lot of pressure on your stomach. Again, we’re going back to that valve, which can become a bit lax and cause acid to track up.
“Avoid lying down after a meal for at least three to four hours. When we lie flat, the sphincter relaxes, and acid can return to the oesophagus.
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“If you have symptoms, prop up your pillows so your chest is slightly higher than your waist, so you’re just slouched up a little bit. Again, avoid lying flat. It really, really works a treat.
“Don’t wear tight clothes. We all want to loosen that button on your jeans after a meal, but actually just get into looser clothing because tight clothes can actually put a lot of pressure on your stomach as well.
“Gentle teas like chamomile work really well. Ginger tea is fantastic. A lot of people turn to mint. Now mint is great if you’ve got IBS or tummy cramps, but actually for reflux it can make the problem worse. So stick to ginger tea or chamomile tea.
“Avoid certain foods as well. Knowing your triggers. So keep a diary. I’m a big one for diaries. Look at when you get your symptoms, what have you had or done that day that could have exacerbated them. Taking them into your doctor is a real help to us. And that and also managing your weight. I think that goes without saying can make a big difference.”