Austin Abrams, Algee Smith and Storm Reed are not returning for series three, while Barbie Ferreira, who played Kat, left at the end of season two.
Angus Cloud, who played Fezco, died in July 2023 at the age of 25.
Cloud’s death and Hollywood strikes halted production of the show’s third season, which was due to start in December 2023.
It’s not yet known how Cloud’s absence will affect storylines in the season.
Colman Domingo, who plays Ali on the show, told Vanity Fair, external in 2024 that Fezco’s character was originally going to feature strongly in the series.
“I’m sure it affected not only the creation of season three, because [Angus] was going to be a very strong part of it… We came together as a cast many times to grieve, to mourn, to laugh and enjoy all the things we know about Angus,” he said.
Euphoria is one of HBO’s biggest hits and is its fourth most-watched show behind Game of Thrones, The Last of Us and House of the Dragon.
Zendaya has won two Emmys and a Golden Globe for her performance as the lead, with Domingo winning a guest actor Emmy for the series.