Peter Henley has presented 302 Politics Shows, 254 editions of Sunday Politics and 190 editions of Politics South.
His final Politics South show on Sunday highlighted his early involvement in national stories about bereavement leave and healthy eating.
One previous programme featured Berkshire mother Lucy Herd, whose campaign for bereavement leave following the death of her son Jack eventually led to legislation known as “Jack’s Law”.
A 2006 report on future Prime Minister Boris Johnson’s criticism of Jamie Oliver’s health eating campaign for children became a national news story.
Peter Henley joined the BBC in 2001 after stints as a reporter for Radio 210 in Reading and ITV in the south of England.
Ms Moyse said: “For nearly three decades, Peter’s curiosity and his ability to drill down into policy and issues that affect all our lives have been central to BBC South’s political coverage.
“We thank him for his outstanding contribution and commitment to serving our audiences on TV, Radio and Online.”