Caelan Doris will captain Leinster as he is set to make his 100th appearence in blue during Saturday’s visit to Connacht.
Niall Smyth is set to make his debut for the province and will be joined in the front row by Gus McCarthy and Jack Boyle.
James Lowe returns for his first appearance since last month’s win over Munster and lines out on the wing, one try shy of equalling Shane Horgan’s Leinster record of 69, with Joshua Kenny on the opposite flank and Ciaran Frawley named at full-back.
South African RG Snyman and James Ryan combine in the second row, with centurion Caelan Doris joined by Will Connors and Alex Soroka.
Harry Byrne and Fintan Gunne start in the half-backs, with Charlie Tector partnering Garry Ringrose in midfield.
Leinster sit fifth in the URC table, Leo Cullen’s side have won nine games in a row in all competitions, their last defeat coming against Munster in October last year.
Leinster: C Frawley; J Kenny, G Ringrose, C Tector, J Lowe; H Byrne, F Gunne; J Boyle, G McCarthy, N Smyth; RG Snyman, J Ryan; A Soroka, W Connors, C Doris (capt).
Replacements: R Kelleher, J Cahir, A Sparrow, B Deeny, D Mangan, S Penny, L McGrath, R Moloney.