In a post on social media, Ulster Unionist Party (UUP) MLA for Fermanagh and South Tyrone, Diana Armstrong, said she was “deeply concerned” after learning of the crash.
“My thoughts are with all those affected by this collision, my thanks go to the PSNI and emergency services who attended to provide immediate assistance and hospital transfers,” she said.
“Holding those affected and their families in my thoughts and prayers at this difficult time.”
Local Democratic Unionist Party (DUP) councillor, Scott Armstrong, said he was “deeply shocked and saddened”.
“Incidents such as this remind us all of the fragility of life and the importance of road safety and looking out for one another on our roads,” he added.
Four other people died over the weekend in road traffic collisions in the Republic of Ireland.