A man has been taken to hospital with serious injuries after a crash involving a bus and a car.
Derbyshire Police said the A608 Station Road in Langley Mill, Derbyshire, was shut just after 04:00 GMT on Saturday.
It stayed closed for several hours will investigation work took place, the force added, and reopened at 11:45.
Anyone with information, including dashcam footage, has been urged to contact police.