Ospreys will be led by Wales captain Jac Morgan, while Ross Moriarty returns on the replacements bench after serving his suspension.
Head coach JP Pietersen has given 18-year-old Zekhethelo Siyaya a first start at full-back.
Double South African winning captain Siya Kolisi has been named in the squad for the short tour but will not feature in Bridgend, while Springboks lock Eben Etzebeth is set to miss the rest of the season because of a hip problem.
Ospreys: Hopkins; L Morgan, Bishoff, Watkin, Kasende; Edwards, Hardy; G Thomas, Parry, Botha, Sutton, R Smith, Ratti, J Morgan (capt), Morris.
Replacements: Daniel, Phillips, Warren, Moriarty, Deaves, Morgan-Williams, P Cokanasiga, Walsh.
Sharks: Siyaya; E van der Merwe, Malan, Esterhuizen (capt), Hooker; J Smith, Hendrikse; Ganyane, Mbatha, Jacobs, Jenkins, van Heerden, Buthelezi, V Tshituka, M Tshituka,
Replacements: Swart, Nche, Koch, Rahl, Hatton, Davids, Masuku, Julius.
Referee: Mike Adamson (Scotland)
Assistant referees: Craig Evans (Wales), Marcus Caudle (WRU).
TMO: Andrew McMenemy (SRU).