In the 105th edition of the Italian one-day race, the peloton faced a challenging course of over 196 kilometers. After the traditional start in Busto Arsizio, the breakaway riders quickly made their move. The five escapees built a lead of more than six minutes on the local circuit, which featured the climbs of Montello and Salita dei Ronchi. When the peloton, with Team Visma | Lease a Bike well positioned at the front, increased the pace, the leaders were quickly reeled in.
About 45 kilometers from the finish in Varese, several new attacks from the peloton kicked off the final stretch. The yellow-and-black team immediately played its part, with Davide Piganzoli joining Quinn Simmons in an attack. When the Italian was caught, Jorgenson, Widar and Tom Pidcock launched the next acceleration shortly afterwards. That proved to be the decisive move of the race. The trio stayed clear of the peloton and sprinted for the victory. Widar claimed his first professional victory, while Jorgenson finished third.