A stretch of the M56 near Manchester Airport has been closed in both directions as emergency services respond to an incident.
Greater Manchester Police, North West Ambulance Service and National Highways traffic officers are all in attendance.
The motorway is closed between junctions two at Sharston and five at Manchester Airport.
Queues are building up in either direction approaching the scene from the M56 in Trafford and the M60.
Police have also been seen in attendance on nearby local roads.
Further details about the nature of the incident are yet to be confirmed.