Dale Street/Water Street, between Exchange Street East and Lower Castle Street, will be closed from 08:00 BST on 18 October until 20:00 on 20 October.
The same section of road will close again to facilitate the safe removal of artworks from 08:00 GMT on 2 November until 20:00 on 3 November.
During the event itself, Dale Street will be closed to general traffic from Byrom Street to Water Street where it meets The Strand, along with the side streets on to Water Street.
These closures will be in place from 17:00 to 21:00 each evening from Friday to 1 November.
The side streets include:
Lower Castle St
Fenwick St
Rumford St
Covent Garden
Drury Lane
Tower Gardens
Drivers are advised to allow extra time for their journeys and use alternative routes where possible. Signed diversions will be in place during all closures.
Meanwhile, find out all you need to know about Merseyrail changes.