He will be flanked by Jean-Clair Todibo and Nayef Aguerd, with Senegal international El Hadji Malick Diouf continuing at left wing-back.
The midfield will be anchored by Argentina international Rodríguez, with Ward-Prowse and Tomáš Souček playing slightly ahead of him.
The Czechia captain scored in our 2-1 Premier League win at Molineux in December 2024, as did captain Jarrod Bowen.
Ward-Prowse and Lucas Paquetá, who moves into a more advanced attacking role tonight, both scored in a 2-1 Premier League victory at Wolves in April 2024.
Bowen, who grew up not too far from Wolverhampton in the Herefordshire town of Leominster, scored the winner and assisted Souček’s goal in the December 2024 success. He found the net in Premier League wins over Wolves at London Stadium in September 2020, when he scored twice, October 2022 and December 2023.
The England forward also scored in a thrilling 3-2 Premier League victory at Molineux in April 2021, taking his overall tally to six goals and an assist in eleven career appearances for West Ham against tonight’s opponents.
The bench will be filled by goalkeeper Mads Hermansen, wing-back Ollie Scarles, midfielders Freddie Potts, Lewis Orford and Andy Irving and striker Callum Marshall.
Wolverhampton Wanderers: Johnstone, R. Gomes, Mosquera, Agbadou, S. Bueno, H. Bueno, André, Bellegarde, López, Arias, Hwang ©
Subs: Bentley (GK), Tchatchoua, Doherty, Wolfe, Munetsi, J. Gomes, Chirewa, Kalajdžić, Strand Larsen
West Ham United: Areola, Walker-Peters, Todibo, Mavropanos, Aguerd, Diouf, Rodríguez, Ward-Prowse, Souček, Paquetá, Bowen ©
Subs: Hermansen (GK), Scarles, Kilman, Potts, Orford, Irving, Füllkrug, Wilson, Marshall
Referee: Darren England