Yes, Blomkamp’s film would have predicted the modern trend of ignoring all the less-loved sequels and taking place in its own timeline. This film would have picked up some time after Aliens, ignoring the fate of Newt and Hicks in Alien 3, and would have set Ripley to face off with another Alien Queen.
Of course the actual fifth Alien movie ended up being Prometheus, Ridley Scott’s exploration of the “space jockey” (now renamed “engineers”) from the original film. The xenomorph, however, would not appear again in earnest until Scott’s Alien: Covenant, which is a more traditional prequel with the titular monster on a rampage on a spaceship. It also featured much of the same philosophical and religious wondering that marked Prometheus, making it something of a mixed bag for fans.
Weaver also discussed a different fifth Alien film, one written by Walter Hill. In addition to being a producer who helped shepherd the original Alien from a gonzo script by Ronald Shusett and Dan O’Bannon into the classic today, Hill is an accomplished filmmaker in his own right, albeit better known for gritty crime flicks like The Warriors and 48 Hrs.
“Walter Hill has written about 50 pages. Maybe, by now, he’s written more about where Ripley might be now,” Weaver revealed. “And although I’ve never particularly wanted to go back to the series, there’s something about her experience being sidelined now, probably by this society, by this company, by this world and being probably around 200 years old, but still [being] Ripley and you know, presumably these problems [are] still out there.”
Weaver remains uncertain about the status of Hill’s current script, noting that it would be “a very different kind of story” than the original Alien. But it sounds like she’s interested in hearing what Hill has in mind—provided that Scott doesn’t tell him to get away too.