Reading and Leeds bosses said the twin events would be the only UK festival appearances for all six headliners next year.
The West Yorkshire site will also feature a Thursday headline performance for the first time, with rock band Kasabian set to take to the stage.
Irish rap trio Kneecap, pop singer Jade and grime artist Skepta are also on the bill across the weekend, alongside US singers Sombr and Role Model.
Other artists confirmed include up-and-coming singer Skye Newman, Manchester-based DJ Josh Baker, Irish producer Kettama, US rock band Geese, Slovakian singer Adéla and rock band Keo.
Dutch DJ Chris Stussy will play Reading only, with more acts yet to be announced.
US pop star Chappell Roan and US rapper Travis Scott were among the headliners at the festivals this summer, alongside Metal band Bring Me The Horizon and singer-songwriter Hozier.
The events will take place at Reading’s Richfield Avenue and Bramham Park in Leeds between 27 to 30 August, with artists rotating which days they perform on.
Tickets will go on general sale on Thursday, with presales already live.