The incident occurred earlier this morning (Friday, January 2) as a crash took place in the centre of the city.
Now, the A420 High Street has been closed in both directions by emergency services between The Plain and Longwall Street.
READ MORE: Major city road closed in both directions after crash
Help support trusted local news
Sign up for a digital subscription now: https://www.oxfordmail.co.uk/subscribe/
As a digital subscriber you will get:
Unlimited access to the Oxford Mail website
Advert-light access
Reader rewards
Full access to our app
Emergency services are currently in attendance, with Thames Valley Police officers among those at the scene.
The force has provided an update on the situation and said in a statement: “The High Street is currently closed in both directions following a serious injury road traffic collision at around 2.40am today (2/1) in Oxford.
“Officers are currently at the scene, and the road remains closed between Iffley Road and The Plain and is likely to remain shut for some time.
“Please avoid the area at this time.”