Aging is a privilege we should all enthusiastically embrace; but with all the longevity supplements, biohacking methods, anti-aging strategies, and injectable treatments swirling around, it’s easy to lose the plot. When it comes to longevity, how we care for ourselves now is the biggest indicator of how we’ll age. “Clinically, healthy aging means keeping people active, mentally sharp, and able to fully participate in their lives for as long as possible,” explains physician and founder of Parsley Health Robin Berzin, MD. “Living longer without strength, mobility, or cognitive clarity isn’t a win.” The distinction between lifespan versus health span is an important one. “The goal with longevity isn’t just more time; it’s more quality time,” adds Dr. Berzin. Anti-aging supplements, then, focus not on looking better, but supporting you feeling better.

Vogue’s Favorite Longevity Supplements:

Genetics play a role, of course, but not as much as you think. “Genetics are the dictionary, but behavior writes our story,” says board-certified physician and founder of LifeSpan Medicine Chris Renna, DO. “Behavior influences the epigenetic changes that play the biggest role in who we are and what we are able to do.” There are a few evidence-backed pillars of longevity science. “Physical activity (especially resistance training), sleep quality, nutrition, and stress regulation remain the strongest levers we have to healthy aging, according to scientific research,” explains doctor and clinical advisor in aging research at King’s College University Michael Sagner, MD. “Most underestimate the power of the basics, including caring for your mental health and leading a fulfilling social life, and immediately jump to injections, infusions, and unproven ‘fancy’ interventions.”

However, modern life, stress, and nutrition means we all may need a little extra help from time to time and the best longevity supplements can act as a support system to help fill in any nutritional gaps. If you want to embrace aging with open arms, but look and feel as good as humanly possible while doing it, we’ve tapped three doctors and longevity experts to dish on the best longevity supplements and strategies to support longer, healthier years.