Wales make two changes to the XV that lost in Cork with Lewis Edwards making his first start of the campaign at full-back while Dom Kossuth steps up from the bench to replace injured Dragons number eight Evan Minto.
They go for six forwards on the bench with Alex Ridgway back after scoring his first try for Bath in their Prem Rugby Cup semi-final defeat by Leicester last weekend.
Wales are without fly-half Carwyn Leggatt-Jones, who started the first three rounds and came on against Ireland, because he has been released for Scarlets’ rearranged United Rugby Championship fixture at Connacht.
Whiffin believes the Six Nations performances will lead to plenty of selection headaches for the management team ahead of the World Championship.
“We’ve grown a fair bit of depth because we will have used 35 players, given opportunities and can pick horses for courses,” he said.
“I’ve got to get the group down to 30 for the World Championship and it will be a good group whoever goes out there.”
Wales are drawn against South Africa, hosts Georgia and Uruguay in the group stages of the expanded 16-team tournament that starts at the end of June.