The Dragons will fly the flag for Welsh rugby when they take on Zebre at Stadio Sergio Lanfranchi.
The Men of Gwent are the sole Welsh representatives in the Challenge Cup quarter-finals – with a place in the semi-finals on the line.
Filo Tiatia has made just one change to the side that beat Stade Francais in Paris last weekend, with Levi Douglas ruled out through injury.
The match is being broadcast on S4C and Premier Sport 1. You can also follow it live in the blog below.
Kick-off is at 8pm.
Zebre: Giovanni Montemauri; Mirko Belloni, Giulio Bertaccini, Marco Zanon, Jacopo Trulla; Giacomo da Re, Garcia; Muhamed Hasa, Tommaso di Bartolomeo, Ion Neculai, Matteo Canali, Leonardo Krumov (capt), Alessandro Ortombina, Bautista Stavile, Davide Odiase.
Replacements: Giovanni Quattrini, Luca Franceschetto, Juan-Manuel Pitinari, Giacomo Ferrari, Giovanni Licata, Alessandro Fusco, Damiano Mazza, Samuele Locatelli
Dragons: Angus O’Brien (co-capt); David Richards, Fine Inisi, Aneurin Owen, Rio Dyer; Tinus de Beer, Niall Armstrong; Rodrigo Martinez, Brodie Coghlan, Chris Coleman, Ryan Woodman, Ben Carter (co-capt), Harrison Keddie, Thomas Young, Aaron Wainwright.
Replacements: Elliot Dee, Wyn Jones, Owain James, Seb Davies, Shane Lewis-Hughes, Morgan Lloyd, Fetuli Paea, Huw Anderson.
Referee: Luke Pearce (RFU)
Live updates below: