Beefeater will close all 106 UK restaurants on September 10 as part of a major restructuring by parent company Whitbread.
Up to 3,800 jobs are at risk nationwide as Whitbread phases out both its Beefeater and Brewers Fayre brands.
It means that the Great Yarmouth branch will be soon disappearing.
Dominic Paul, chief executive of Whitbread, said: “We always challenge ourselves to improve and, in light of significant cost increases in the form of business rates and national insurance, as well as the implied market discount to our inherent value, we’ve looked hard at the options open to us to maximise value creation over the medium and long-term.
“This has been a rigorous process and we’ve approached all options with an open mind.
“Our new five-year plan builds on our strengths and drives a significant acceleration of our strategy.
“This plan will transform Whitbread into a higher-margin, higher-returning pure-play hotel business.”
The closures are part of Whitbread’s new five-year growth strategy to refocus the business and reduce costs by £250 million.
The company will convert some of the restaurant sites into additional Premier Inn rooms and intends to sell off around £1.5 billion worth of freehold properties to fund further growth.
Whitbread currently operates around 86,600 hotel rooms and plans to increase that number to 96,000 by the 2031 financial year.
The company said it will try to redeploy affected staff into other roles within the business but expects significant job losses.
A spokesman for Whitbread said: “We will do all we can to support those colleagues affected.”