“Che is a really exciting talent, and the way that he has performed for the Dragons has been outstanding,” said Tandy.
There is no place for in-form Scarlets wing Macs Page, but Dragons’ Dyer, who has also started the season strongly, does earn a recall.
The 26-year-old won the most recent of his 24 caps against South Africa last November.
Leicester’s Gabriel Hamer-Webb, who made his Wales debut against Scotland in the Six Nations, also returns after missing out in the summer.
Lock Davies, who moved from Cardiff to Dragons in the summer of 2025, will aim to win his first cap since the 2022 Six Nations.
Dynamic back-row forward Basham has started the season strongly for Cardiff and gets the nod ahead of fit-again Faletau, who made his first appearance of the campaign for Cardiff at Northampton on Sunday.
Basham won the last of his 17 caps against England in the 2024 Six Nations.
“At the end of last season when Cardiff were playing the South African teams, Taine was really impressive and really fronted up,” said Tandy.
“He has kicked on and settled into Cardiff really well. He has been telling me all about his line breaks! He’s a great character, and this is a great opportunity.”
Specialist open-side flanker Reffell, who featured in the summer Tests and has been in fine form for Leicester, misses out through a knee injury.
He will be out for four to six weeks, meaning he will target a return for Tigers after the Nations Championship.