Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer
Study population We studied three independent cohorts of patients with NSCLC who were treated with PD-1-based immunotherapies in…
Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer
de Magalhaes, J. P. How ageing processes influence cancer. Nat. Rev. Cancer 13, 357–365 (2013). Article PubMed Google…
Mechanical confinement governs phenotypic plasticity in melanoma
Zebrafish husbandry Stable transgenic zebrafish lines were kept at 28.5 °C in a dedicated aquatics facility with a 14 h…
Concurrent loss of the Y chromosome in cancer and T cells impacts outcome
TCGA data acquisition and processing In this study, we used bulk RNA-seq, WES somatic mutation data, and clinical…