Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer
de Magalhaes, J. P. How ageing processes influence cancer. Nat. Rev. Cancer 13, 357–365 (2013). Article PubMed Google…
Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions
Ethics Our study complies with all relevant ethical regulations and was approved by the institutional review boards at…
Feasibility and clinical utility of expanded genomic newborn screening in the Early Check program
Enrollment rates Between 28 September 2023 and 10 June 2024 (~8.5 months), a total of 2,125 newborns were enrolled.…
Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function
Ethics statement This study included de-identified data from participants who had consented to the use of their anonymized…
Tip Sheet: What cancer patients need to know about tumor markers, a new cancer genetics atlas — and educational programs for students and teachers
SEATTLE — Sept. 3, 2025 — Below are summaries of recent Fred Hutch Cancer Center research findings, patient…
Tip Sheet: What cancer patients need to know about tumor markers, a new cancer genetics atlas — and educational programs for students and teachers
SEATTLE — Sept. 3, 2025 — Below are summaries of recent Fred Hutch Cancer Center research findings, patient…
Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis
Ethical regulations This study was conducted under approved UKB application no. 56844. Clinical samples were obtained with informed…
Mutational landscape of triple-negative breast cancer in African American women
Patient population Paired tumor and normal samples from 513 self-identified AA women with TNBC were interrogated by WES.…
Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity
BRG1 binding exhibits a linear response to its dosage In mES cells, Brg1 encodes the major catalytic subunit…
Temporal genomic dynamics shape clinical trajectory in multiple myeloma
Maura, F. et al. Moving from cancer burden to cancer genomics for smoldering myeloma: a review. JAMA Oncol.…
The new vaccines and treatments that could stop cancer in its tracks
The next advances in defeating cancer may come from a surprising place – our own natural defence mechanisms…
Imaging-based multimodal profiling of single cells with STAMP
Single-cell RNA sequencing (scRNA-seq) has dramatically advanced our ability to dissect complex biological systems at cellular resolution. However,…