Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity
Protein coding variation and population structure in 44,028 South Asian exome sequences We identified a total of 4,723,926…
AI-based chest X-ray prioritization in the lung cancer diagnostic pathway: the LungIMPACT randomized controlled trial
This large, multisite randomized study has shown that AI prioritization of CXRs did not improve the speed of…
A clinical environment simulator for dynamic AI evaluation
Goh, E. et al. Large language model influence on diagnostic reasoning: a randomized clinical trial. JAMA Netw. Open…
Vegetarian diets and cancer risk: pooled analysis of 1.8 million women and men in nine prospective studies on three continents
Study population The study design and data harmonisation process have been described in detail elsewhere [17]. Briefly, prospective…
Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila
Drosophila stock maintenance PCNA::EGFP flies used for interphase-staged Pico-C were generously provided by S. A. Blythe and E.…
PRIMARY-AI: outcomes-based standards to safeguard primary care in the AI era
School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China Dian Zeng, Zehua Jiang, Yiming Qin & Tien…
Reliability of LLMs as medical assistants for the general public: a randomized preregistered study
The study employed a between-subjects design with three treatment groups and a control. Before the treatment phase, participants…
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling
CTNNB1 hotspot mutational patterns are tissue-specific We analyzed 9,248 tumors with CTNNB1 mutations in the COSMIC database (Fig.…
Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial
Study participants and clinical trial design The FMT-LUMINate trial (NCT04951583) is a multicenter, open-label, phase 2 trial that…
‘Foul odour’ could be hidden sign of cancer
The NHS, Cancer Research UK and Mayo Clinc have all urged people to act as soon as they…
Holistic evaluation of large language models for medical tasks with MedHELM
Papers with Code. Question answering on MedQA (USMLE). https://paperswithcode.com/sota/question-answering-on-medqa-usmle (2024). Khosravi, M., Zare, Z., Mojtabaeian, S. M. &…
An LLM chatbot to facilitate primary-to-specialist care transitions: a randomized controlled trial
Ethics approval The Chinese Academy of Medical Sciences and Peking Union Medical College and the local medical ethics…