Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153,…
Gene-expression patterns can be used to estimate mortality risk and chronological age – Nature
Gene-expression patterns can be used to estimate mortality risk and chronological age Nature‘Universal’ aging clocks offer new clues to…
Evaluating a digital serious game for learning medical terminology in a randomized controlled trial
Smith, S., Fisher, J. & Goff, I. MediLex: the medical jargon-busting game. Clin. Teach. 14, 273–278 (2017). Google…
‘Virtual cell’ captures most-basic process of life: bacterial division
A computer generated illustration of a simulated cell in the early stages of division. Credit: Zane Thornburg For…
NutriMatch: harmonizing food composition databases with large language models for enhanced nutritional prediction
Data collection We utilized data from the 10K Project, a prospective human cohort study involving over 10,000 healthy…
Proteome-wide model for human disease genetics
Statistics and reproducibility This study is based on analysis of large-scale sequencing and variant annotation datasets (UniRef58, UKBB17,…
can it produce the next big breakthrough?
No one could accuse Demis Hassabis of dreaming small. In 2016, the company he co-founded, DeepMind, shocked the…
Reporting guidelines for studies involving generative artificial intelligence applications: what do I use, and when?
The rise in publications addressing the use of general artificial intelligence (GAI), namely large language models (LLMs), for…
Loss of macroevolutionary species fitness explains the rise and fall of clades
Raup, D. M. Biological extinction in Earth history. Science 231, 1528–1533 (1986). Article CAS PubMed Google Scholar Benton,…
Nucleotide dependency analysis of genomic language models detects functional elements
SpeciesLM training For SpeciesLM metazoa, we obtained metazoan genomes comprising 494 different species from the Ensembl 110 database36.…
CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold
Input embeddings In CellNavi, we use single-cell raw count matrices as the only input. Specifically, the single-cell sequencing…
Spatial architecture of development and disease
Bressan, D., Battistoni, G. & Hannon, G. J. The dawn of spatial omics. Science 381, eabq4964 (2023). Article …