A universal entropic pulling force caused by binding
Entropic force in a diatomic molecule To illustrate the concept of entropic force, we begin with a simple…
Genetic controllers for enhancing the evolutionary longevity of synthetic gene circuits in bacteria
Modelling and quantifying gene circuit evolution We develop an ordinary differential equation model of host-circuit interactions31,33 and augment…
Quantum computing for faster enzyme discovery and engineering
Nielsen, M. A. & Chuang, I. L. Quantum Computation and Quantum Information: 10th Anniversary Edition (Cambridge Univ. Press,…
Efficient sequence alignment against millions of prokaryotic genomes with LexicMap
Probe generation Probes, also referred to as ‘masks’ in the LexicHash paper, consist of a fixed number (m = 20,000…
Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation
Nonparametric baselines We design two nonparametric baselines that we refer to as perturbed mean and matching mean. Perturbed…
Clone copy number diversity is linked to survival in lung cancer
The ALPACA algorithm We introduce ALPACA, an algorithm to infer allele-specific copy-number profiles of every tumour clone, given…