Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function
Ethics statement This study included de-identified data from participants who had consented to the use of their anonymized…
Gene expression maps explain why diseases often occur together
By grouping patients based on gene activity, scientists show that shared molecular pathways, especially immune-related ones, help explain…
Genetic and molecular landscape of comorbidities in people living with HIV
Participants from the 2000HIV study The 2000HIV study is a prospective multicentric observational longitudinal cohort of virally suppressed…
ADHD Meds Offer Benefits Far Beyond Core Symptom Relief
Attention-deficit/hyperactivity disorder (ADHD) medications appeared to reduce the risk for suicide, drug misuse, transport incidents, and criminal activity,…
Inappropriate Prescribing Tied to Mortality Risk in Seniors
TOPLINE: Older adults who were prescribed medications flagged as potentially inappropriate had an increased risk for mortality, with…
Countrywide natural experiment links built environment to physical activity
Study design We conducted a countrywide, prospective, longitudinal physical activity study of US residents that evaluated their physical…
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling
Fogg, C. et al. The dynamics of frailty development and progression in older adults in primary care in…
Shotgun sequencing of airborne eDNA achieves rapid assessment of whole biomes, population genetics and genomic variation
Permitting The analysis of human-derived eDNA from field obtained samples and human-related sampling was conducted with University of…
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design
Ethics statement This study complies with all relevant ethical regulations and was conducted in accordance with the research…