SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry
Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760–1764…
Epigenetic editing makes its mark
Epigenetic modifications to DNA (yellow), such as those catalysed by DNA methyltransferase enzymes (blue, centre) control gene expression.Credit:…
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing
Adapting prime editing for mammalian histone mutagenesis Mouse canonical histone H3 is encoded by nine H3.1 and three…
World-first: therapy to make cells young again given to a person
Scientists are attempting to rejuvenate cells in the optic nerve (nerve fibres in red), which channels information from…
De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion
Vermunt, M. W., Zhang, D. & Blobel, G. A. The interdependence of gene-regulatory elements and the 3D genome.…
New Research Links Daily Multivitamins to Slower Biological Aging
In a randomized clinical trial of older adults, researchers found that taking multivitamins for two years modestly slowed…
Daily multivitamin slows signs of biological ageing
Taking multivitamins daily was associated with changes in epigenetic ageing ‘clocks’.Credit: Halfpoint Images/Getty Taking a multivitamin every day…
Health effects linger 20 generations after rats are exposed to fungicide
Rats that had ancestors who had been exposed to a fungicide experienced health problems. Credit: Kseniia Glazkova/Alamy Exposure…
Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila
Drosophila stock maintenance PCNA::EGFP flies used for interphase-staged Pico-C were generously provided by S. A. Blythe and E.…
Why biological clocks get our ‘true age’ wrong – and how AI could help
You may be chronologically older than your “true age” REUTERS/Toru Hanai When I first started writing about ageing…
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes
Iyer, L. M., Abhiman, S. & Aravind, L. Natural History of Eukaryotic DNA Methylation Systems, Vol. 101 (Elsevier,…
Cell-type- and locus-specific epigenetic editing of memory expression
All animals and procedures used in this study were approved by the Veterinary Office of the Federal Council…