Characterization of induced cohesin loop extrusion trajectories in living cells
Experiments performed in this study did not require ethics board approval. Cell culture HAP1 cells were cultured in…
Spatial joint profiling of DNA methylome and transcriptome in tissues
Tissue slide preparation Mouse C57 embryo sagittal frozen sections (MF-104-11-C57 and MF-104-13-C57) were purchased from Zyagen. Freshly collected…
Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity
BRG1 binding exhibits a linear response to its dosage In mES cells, Brg1 encodes the major catalytic subunit…
Systematic decoding of functional enhancer connectomes and risk variants in human glioma
The study was approved by the Ethics Institutional Review Boards of the First Affiliated Hospital of Sun Yat-sen…
Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize
Quantification of functional cis-variation To focus on genetic differences affecting TF binding in cis, we quantified TF footprints…