From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes
Strain culture and DNA extraction We used a collection of S. cerevisiae isolates that were previously sequenced using…
The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution
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Fueling chromosomal gene diversification and artificial evolution with CRISPR | Genome Biology
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Clarifying Uncertain Genetic Tests in Cancer Treatment
Cancer treatment is becoming more personalised. By considering a patient’s unique genetic and molecular profile, along with their…
The evolution of hominin bipedalism in two steps
Sample collection Human developmental stages E45–E72 were obtained from first-trimester termination procedures conducted at the Birth Defects Research…
Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize
Quantification of functional cis-variation To focus on genetic differences affecting TF binding in cis, we quantified TF footprints…
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression
James, S. L. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354…
Methods and applications of in vivo CRISPR screening
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