Gene Function - United Kingdom News Beep

Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

October 22, 2025

Institute of Medical Genetics, University of Zurich, Zurich, Switzerland Reza Asadollahi, Paranchai Boonsawat, Dennis Kraemer & Anita Rauch Faculty of Engineering and…

GGenetics

Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs

October 21, 2025

Cohorts We used published data (GEO accession no. GSE162632) to study the effect of 12 h of ex vivo…

GGenetics

Redefining cellular reprogramming with advanced genomic technologies

October 18, 2025

Briggs, R. & King, T. J. Transplantation of living nuclei from blastula cells into enucleated Frogs’ eggs. Proc.…

GGenetics

Characterization of induced cohesin loop extrusion trajectories in living cells

October 18, 2025

Experiments performed in this study did not require ethics board approval. Cell culture HAP1 cells were cultured in…

GGenetics

Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health

October 11, 2025

Ethics Our research complies with all relevant ethical regulations. All studies included in this research were approved by…

GGenetics

Nucleotide dependency analysis of genomic language models detects functional elements

October 10, 2025

SpeciesLM training For SpeciesLM metazoa, we obtained metazoan genomes comprising 494 different species from the Ensembl 110 database36.…

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Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer

October 10, 2025

Study population We studied three independent cohorts of patients with NSCLC who were treated with PD-1-based immunotherapies in…

GGenetics

A genetic map of human metabolism across the allele frequency spectrum

October 4, 2025

Study design The UKB is a prospective cohort study from the UK that contains more than 500,000 volunteers…

GGenetics

Spatial architecture of development and disease

October 1, 2025

Bressan, D., Battistoni, G. & Hannon, G. J. The dawn of spatial omics. Science 381, eabq4964 (2023). Article …

GGenetics

Limited overlap between genetic effects on disease susceptibility and disease survival

September 30, 2025

Ethics statement This study was conducted in compliance with the relevant ethical guidelines and approved by the appropriate…

GGenetics

Advances in haplotype phasing and genotype imputation

September 24, 2025

Voight, B. F., Kudaravalli, S., Wen, X. & Pritchard, J. K. A map of recent positive selection in…

GGenetics

September 24, 2025

Puttick, M. N. et al. Curr. Biol. 28, 733–745.e2 (2018). Article PubMed CAS Google Scholar Shaw, A. J,…