Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling
Fogg, C. et al. The dynamics of frailty development and progression in older adults in primary care in…
Archived natural DNA samplers reveal four decades of biodiversity change across the tree of life
Specimen bank data This research complies with all relevant ethical regulations. All study protocols are approved by the…
Control of collective activity to crystallize an oscillator gas
Toner, J., Tu, Y. & Ramaswamy, S. Hydrodynamics and phases of flocks. Ann. Phys. 318, 170–244 (2005). ADS …
The Platinum Pedigree: a long-read benchmark for genetic variants
Gonzaga-Jauregui, C., Lupski, J. R. & Gibbs, R. A. Human genome sequencing in health and disease. Annu. Rev.…
Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines
The success of large language models in knowledge representation has spawned efforts to apply the foundation model concept…
Predicting resistance to chemotherapy using chromosomal instability signatures
CIN signatures as biomarkers of chemotherapy resistance The presence of CIN in a tumor has long been recognized…
Shifting hotspot of tropical cyclone clusters in a warming climate
Probabilistic TC cluster model To statistically analyse the climatology of TC clusters, we design a probabilistic TC cluster…
Detecting and quantifying clonal selection in somatic stem cells
Ethical approval Patient samples were collected with informed consent under the Mechanisms of Age-Related Clonal Haematopoiesis (MARCH) Study.…
GeneAgent: self-verification language agent for gene-set analysis using domain databases
Model setting and data collection In this work, we utilized GPT-4 (version 20230613) as the backend model via…
Bridging psychiatry and rare genetic diseases: a scoping review of therapeutic strategies and diagnostic delay paired with healthcare economic burden analysis | Orphanet Journal of Rare Diseases
Nguengang Wakap S, Lambert DM, Olry A, Rodwell C, Gueydan C, Lanneau V, Murphy D, Le Cam Y,…
Flatland wakes based on leaky hyperbolic polaritons
Zhang, Q. et al. Interface nano-optics with van der Waals polaritons. Nature 597, 187–195 (2021). CAS PubMed Google…
Pangenome analysis provides insights into legume evolution and breeding
Foyer, C. H. et al. Neglecting legumes has compromised human health and sustainable food production. Nat. Plants 2,…