Lifestyle and environmental factors affect health and ageing more than our genes
The researchers used data from nearly half a million UK Biobank participants to assess the influence of 164…
Violent experiences alter the genome in ways that persist for generations
Violence and trauma leave inheritable markers on a person’s genome that persist over multiple generations, according to a…
Concurrent loss of the Y chromosome in cancer and T cells impacts outcome
TCGA data acquisition and processing In this study, we used bulk RNA-seq, WES somatic mutation data, and clinical…
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design
Ethics statement This study complies with all relevant ethical regulations and was conducted in accordance with the research…
NHS plans to DNA test all babies in England to assess disease risk
The government’s 10-year plan for the NHS, which is set to be revealed over the coming few weeks,…
UK scientists to synthesise human genome to learn more about how DNA works | Genetics
Researchers are embarking on an ambitious project to construct human genetic material from scratch to learn more about…
The NHS plan to genetically test all newborns sounds smart – until it creates patients who aren’t sick
By 2030, every baby born in England could have their entire genome sequenced under a new NHS initiative…
The Somatic Mosaicism across Human Tissues Network
Broad Institute of MIT and Harvard, Cambridge, MA, USA Tim H. H. Coorens, Boxun Zhao, Adam Voshall, Kristin G. Ardlie, Bradley E.…
Targeted in vivo gene integration of a secretion-enabled GLP-1 receptor agonist reverses diet-induced non-genetic obesity and pre-diabetes
Plasmid construction The Exe4 gene was codon-optimized using the GeneSmart codon optimization tool (https://www.genscript.com/gensmart-free-gene-codon-optimization.html) based on the amino…
Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs
Identifying the structures of autism phenotypes To best reflect the complexity of presentations across autistic individuals, we identified…
Cracking the code: Using genetic genealogy to unmask serial criminals
Barbara Rae-Venter, a 76-year-old patent attorney living in Marina, California, thought she’d spend her retirement leisurely playing tennis,…
8-year-old wheelchair-user walks again after receiving experimental drug for rare and fatal genetic condition
An 8-year-old boy, wheelchair-bound due to a rare genetic disease, HPDL deficiency, regained his mobility through an experimental…