Genetic architecture of plasma metabolome in 254,825 individuals
Population characteristics We included 254,825 UKB participants with both metabolomic and genomic data available after quality control. The…
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects
Abul-Husn, N. S. & Kenny, E. E. Personalized medicine and the power of electronic health records. Cell 177,…
Human Genome and Gut Fungi Interact in Chronic Disease Risk
Credit: dimdimich / Getty Images A genome-wide association study has revealed how a person’s unique genetic makeup can…
Research uncovers gene variant role in disease biology
Immune New research has filled in missing links between gene variants that have been implicated in disease through…
Research uncovers gene variant role in disease biology
New research has filled in missing links between gene variants that have been implicated in disease through genome-wide…
African American ancestry study identifies new lung cancer risk factors
Cancer Despite having lower smoking habits than other groups in the U.S., Black Americans are more likely to…
Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants
Kadohisa, M. Effects of odor on emotion, with implications. Front. Syst. Neurosci. 7, 57047 (2013). Zucco, G. M.,…
SLC45A4 is a pain gene encoding a neuronal polyamine transporter
Study Population The UKB is a prospective cohort study that has collected extensive phenotypic and genetic data from…
Psychiatric Disorders and Brain Structure Connected via Genetic Mapping
Credit: Floaria Bicher / iStock / Getty Images Plus Researchers have long hypothesized that the genes influencing the…
LDAK-KVIK performs fast and powerful mixed-model association analysis of quantitative and binary phenotypes
Uffelmann, E. et al. Genome-wide association studies. Nat. Rev. Methods Prim. 1, 59 (2021). CAS Google Scholar Visscher,…
Genetic Variants Linked to Frailty Unlock Aging-Related Therapies
Aging is a highly complex process with substantial heterogeneity in health trajectories between individuals. Frailty is a condition…
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling
Fogg, C. et al. The dynamics of frailty development and progression in older adults in primary care in…