Human Genetics - United Kingdom News Beep

Genetic investigation of sinopulmonary diseases in Vietnam: seeking specific causes from non-specific symptoms | Orphanet Journal of Rare Diseases

October 15, 2025

O’Donnell AE. Bronchiectasis – a clinical review. N Engl J Med. 2022;387(6):533–45. Article PubMed Google Scholar Flume PA,…

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Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health

October 11, 2025

Ethics Our research complies with all relevant ethical regulations. All studies included in this research were approved by…

GGenetics

Nucleotide dependency analysis of genomic language models detects functional elements

October 10, 2025

SpeciesLM training For SpeciesLM metazoa, we obtained metazoan genomes comprising 494 different species from the Ensembl 110 database36.…

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Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer

October 10, 2025

Study population We studied three independent cohorts of patients with NSCLC who were treated with PD-1-based immunotherapies in…

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A novel gene expression stability metric to unveil homeostasis and regulation | Genome Biology

October 10, 2025

K-proportion and gene homeostasis Z-Index identify regulatory genes As cells of the same type and in the same…

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A genetic map of human metabolism across the allele frequency spectrum

October 4, 2025

Study design The UKB is a prospective cohort study from the UK that contains more than 500,000 volunteers…

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Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE | Genome Biology

October 3, 2025

Model overview We consider the following model to incorporate both additive and interaction effects: $${Y}_{i}={\sum }_{j=1}^{M}{G}_{ji}{\beta }_{j}+{\sum }_{j=1}^{M}{S}_{ji}{\gamma…

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Spatial architecture of development and disease

October 1, 2025

Bressan, D., Battistoni, G. & Hannon, G. J. The dawn of spatial omics. Science 381, eabq4964 (2023). Article …

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Limited overlap between genetic effects on disease susceptibility and disease survival

September 30, 2025

Ethics statement This study was conducted in compliance with the relevant ethical guidelines and approved by the appropriate…

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Advances in haplotype phasing and genotype imputation

September 24, 2025

Voight, B. F., Kudaravalli, S., Wen, X. & Pritchard, J. K. A map of recent positive selection in…

GGenetics

September 24, 2025

Puttick, M. N. et al. Curr. Biol. 28, 733–745.e2 (2018). Article PubMed CAS Google Scholar Shaw, A. J,…

GGenetics

Fueling chromosomal gene diversification and artificial evolution with CRISPR | Genome Biology

September 23, 2025

Wilson DS, Keefe AD. Random mutagenesis by PCR. Curr Protoc Mol Biol. 2001;51:8–3. Google Scholar Reetz MT, Wu…