Histological aging signatures for monitoring tissue-specific aging and disease
Data reporting No statistical methods were used to predetermine sample size due to the predetermined sample availability of…
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial
This study of psilocybin assisted-therapy for TRD—to our knowledge, the first RCT in this population to assess feasibility…
Divergent impacts of explainable AI for dermatological diagnosis on clinicians versus lay people
Study design We designed two complementary large-scale experiments to evaluate human−AI collaborative diagnostic performance across expertise levels (Fig.…
Impacts of pollution on the soil microbiome
Rodríguez-Eugenio, N., McLaughlin, M. & Pennock, D. Soil Pollution: A Hidden Reality (FAO, 2018). Montanerella, L. et al.…
Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial
Trial design and oversight The STIMULATE-ICP trial aimed to investigate the efficacy of an enhanced ICP for LC,…
Within-patient gene transfer between transiently and chronically infecting bacteria causes extreme antibiotic resistance during lung infections
Murray, C. J. L. et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet…
Mapping in-cell protein contact sites reveals hijacking of paraspeckles during influenza A virus infection
Immortalized cell lines Human A549 (86012804; ECACC) and HEK293T (CRL-3216; ATCC) cells were cultured in DMEM (11960044; Gibco)…
Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
Marburg virus cases reported in Ugandan ebola outbreak area
Uganda formally reported to the World Health Organization on Tuesday that it had detected a Marburg disease outbreak…
Mobile genetic elements shape microbial diversity and functions in thawing permafrost soils
Data collection, metagenome assembly and binning, gene annotation and taxonomy assignment Our study site, Stordalen Mire, is a…
Complex multicellularity is linked with expanded specialized metabolite production in microorganisms
Fischbach, M. A., Walsh, C. T. & Clardy, J. The evolution of gene collectives: how natural selection drives…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Design We conducted a pragmatic, multicenter, parallel-group cluster-randomized controlled trial across a network of 16 primary care facilities…