Cold activates a BH2 metabolic network promoting longevity and proteostasis
C. elegans strains and maintenance C. elegans were maintained at 20 °C on standard nematode growth medium (NGM) seeded…
Exercise enhances aged chondrocyte health through microRNA-29-enriched extracellular vesicles
Denham, J. & Spencer, S. J. Emerging roles of extracellular vesicles in the intercellular communication for exercise-induced adaptations.…
Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover
Goldstein, J. L. & Brown, M. S. A century of cholesterol and coronaries: from plaques to genes to…
Anti-progestin therapy targets hallmarks of breast cancer risk
The BC-APPS1 study The BC-APPS1 was a single-arm, single-centre phase II study registered under the name ‘a pilot…