Real-world, digital-first delivery of GLP-1 receptor agonist therapy in women
Study population Between 27 November 2024 and 31 January 2025, adult women (female sex at birth) were recruited…
Vitamin B12 absorption and factors associated with the response to long-term oral B12 supplementation: a secondary analysis of data from a B12-deficient Indian rural community
Allen LH, Miller JW, de Groot L, Rosenberg IH, Smith AD, Refsum H, et al. Biomarkers of nutrition…
Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health
Ethical approval This study involves data from human participants that have participated in the OFH program and the…
The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis
Ethical approvals This research complies with all relevant ethical regulations. Animal studies carried out in Leeds were regulated…
Histological aging signatures for monitoring tissue-specific aging and disease
Data reporting No statistical methods were used to predetermine sample size due to the predetermined sample availability of…
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial
This study of psilocybin assisted-therapy for TRD—to our knowledge, the first RCT in this population to assess feasibility…
Divergent impacts of explainable AI for dermatological diagnosis on clinicians versus lay people
Study design We designed two complementary large-scale experiments to evaluate human−AI collaborative diagnostic performance across expertise levels (Fig.…
Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial
Trial design and oversight The STIMULATE-ICP trial aimed to investigate the efficacy of an enhanced ICP for LC,…
Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Design We conducted a pragmatic, multicenter, parallel-group cluster-randomized controlled trial across a network of 16 primary care facilities…
Evaluating the robustness and readiness of large frontier models in health AI applications
Singhal, K. et al. Large language models encode clinical knowledge. Nature 620, 172–180 (2023). Article CAS PubMed PubMed…
Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover
Goldstein, J. L. & Brown, M. S. A century of cholesterol and coronaries: from plaques to genes to…