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Browsing Tag

Metabolic Diseases

37 posts
FFitness
The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis
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The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis

  • August 18, 2026
Ethical approvals This research complies with all relevant ethical regulations. Animal studies carried out in Leeds were regulated…
HHealth
Histological aging signatures for monitoring tissue-specific aging and disease
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Histological aging signatures for monitoring tissue-specific aging and disease

  • August 15, 2026
Data reporting No statistical methods were used to predetermine sample size due to the predetermined sample availability of…
HHealthcare
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial
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Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial

  • August 6, 2026
This study of psilocybin assisted-therapy for TRD—to our knowledge, the first RCT in this population to assess feasibility…
HHealthcare
Divergent impacts of explainable AI for dermatological diagnosis on clinicians versus lay people
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Divergent impacts of explainable AI for dermatological diagnosis on clinicians versus lay people

  • August 5, 2026
Study design We designed two complementary large-scale experiments to evaluate human−AI collaborative diagnostic performance across expertise levels (Fig.…
HHealthcare
Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial
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Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial

  • July 29, 2026
Trial design and oversight The STIMULATE-ICP trial aimed to investigate the efficacy of an enhanced ICP for LC,…
HHealthcare
Health system learning enables generalist neuroimaging models
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Health system learning enables generalist neuroimaging models

  • July 10, 2026
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
HHealthcare
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
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Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial

  • June 26, 2026
Design We conducted a pragmatic, multicenter, parallel-group cluster-randomized controlled trial across a network of 16 primary care facilities…
HHealthcare
Evaluating the robustness and readiness of large frontier models in health AI applications
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Evaluating the robustness and readiness of large frontier models in health AI applications

  • June 26, 2026
Singhal, K. et al. Large language models encode clinical knowledge. Nature 620, 172–180 (2023). Article  CAS  PubMed  PubMed…
TTechnology
Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover
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Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover

  • June 25, 2026
Goldstein, J. L. & Brown, M. S. A century of cholesterol and coronaries: from plaques to genes to…
HHealth
Adiposity and cancer: epidemiology, mechanisms and future perspectives
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Adiposity and cancer: epidemiology, mechanisms and future perspectives

  • June 16, 2026
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis…
HHealth
MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
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MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial

  • June 1, 2026
Study conduct The trial was conducted from 19 May 2022 to 2 March 2026 (data cutoff date) in…
HHealthcare
AI-induced never-skilling in medical education
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AI-induced never-skilling in medical education

  • May 28, 2026
Bajwa, J., Munir, U., Nori, A. & Williams, B. Artificial intelligence in healthcare: transforming the practice of medicine.…
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